Treatment-Resistant Depression (TRD)

A woman seeks help for treatment resistant depression raleigh

Depression affects millions of people, but for some, standard treatments like antidepressants and therapy may not provide enough relief. When depression persists despite trying multiple treatments, it is known as treatment-resistant depression (TRD). At MedPsych, we specialize in helping individuals who struggle with TRD. If you have tried at least two antidepressant medications without significant improvement, you may be experiencing treatment-resistant depression. Our team offers advanced approaches to help you regain stability and improve your quality of life. If you’re seeking effective care for treatment-resistant depression in Raleigh, our experts are here to support you with personalized treatment options.

Why Does Depression Become Treatment Resistant?

Depression can be difficult to treat for various reasons. Some contributing factors to TRD include:

  • Incorrect Diagnosis – Other mental health conditions, such as bipolar disorder, can mimic depression, requiring different treatment approaches.
  • Medication Ineffectiveness – Some individuals do not respond to standard antidepressants due to genetic factors.
  • Underlying Medical Conditions – Conditions like thyroid disorders or chronic inflammation can impact mood and interfere with treatment.
  • Incomplete Treatment Approach – Depression often requires more than just medication; therapy, lifestyle changes, and alternative treatments may be necessary.

Understanding why traditional treatments haven’t worked is the first step toward finding a more effective solution.

 treatment resistant depression raleigh

Signs You May Have Treatment-Resistant Depression

Depression varies from person to person, but when symptoms persist despite treatment, it could be a sign of TRD. Common indicators include:

  • Persistent low mood despite taking prescribed antidepressants
  • Lack of improvement after multiple medication adjustments
  • Severe fatigue that makes daily tasks difficult
  • Emotional numbness or feeling disconnected
  • Increased irritability or mood swings
  • Suicidal thoughts that do not subside with treatment

If these symptoms resonate with you, seeking specialized treatment-resistant depression in Raleigh could make a difference in your recovery.

The Importance of Early Treatment

Major depression is one of the most prevalent mental health conditions, impacting over 21 million American adults (more than 8% of the population) each year, as well as 15% of adolescents aged 12-17. This condition can strip away the joy of daily life, worsen existing health issues, and, in severe cases, lead to suicidal thoughts or actions.

Seeking timely and effective treatment for depression is crucial to preventing it from becoming more severe or resistant to standard therapies. When left untreated or inadequately managed, depression can develop into treatment-resistant depression (TRD), making it harder to find relief. Early intervention with the right combination of therapy, medication, and supportive care can improve outcomes and restore a sense of well-being.

A woman feels relief during treatment resistant depression raleigh

Effective TRD Treatment in Raleigh

At MedPsych, we offer advanced, evidence-based treatments for TRD. If standard antidepressants haven’t worked for you, our specialized services can provide new hope.

Medication Adjustments & Management

Our medication management services focus on optimizing your treatment plan. If previous antidepressants have been ineffective, we explore alternative medications, dosage adjustments, and combination therapies to find what works best for you.

Transcranial Magnetic Stimulation (TMS)

We offer Transcranial Magnetic Stimulation (TMS), a non-invasive therapy that stimulates nerve cells in your brain using magnetic fields. This FDA-approved treatment has shown success in reducing depression symptoms, especially for those who haven’t responded to medication.

Esketamine (Spravato) Therapy 

Esketamine (Spravato) therapy is a groundbreaking treatment for severe and treatment-resistant depression in Raleigh. This therapy works differently from traditional antidepressants, providing rapid symptom relief for individuals who haven’t found success with other treatments.

Psychotherapy & Talk Therapy

Psychotherapy is a key part of managing TRD. Our experienced providers use evidence-based techniques like Cognitive Behavioral Therapy (CBT) and other therapeutic approaches to help you develop healthier thought patterns, improve coping skills, and navigate life’s challenges.

If you’re struggling with TRD, we’re here to help. Explore our services and take the next step toward healing.

A woman talks to her therapist during treatment.

Alternative Ways to Support Depression Treatment

While medical treatments like medication and therapy are essential for managing depression, several lifestyle changes and alternative approaches can enhance your recovery. These strategies work alongside professional care to improve overall well-being and make depression treatment more effective.

Stay Consistent with Treatment

One of the most important things you can do is follow your treatment plan. Skipping therapy sessions or stopping medication too soon can cause symptoms to return. Even if you’re feeling better, continue taking prescribed medications as directed. If you’re struggling with side effects or costs, discuss alternatives with your doctor rather than stopping treatment abruptly.

Reduce Stress and Practice Mindfulness

Chronic stress can make depression harder to manage. For those struggling with treatment-resistant depression in Raleigh, finding effective ways to reduce stress is essential to improving mental well-being. Consider relaxation techniques like:

  • Meditation and mindfulness to calm the mind
  • Yoga or tai chi combines movement with stress relief
  • Journaling to process emotions and track your progress
  • Deep breathing exercises to lower anxiety

Finding a stress-management routine that works for you can improve your mood and resilience over time.

Improve Sleep Habits

Poor sleep can worsen depression, leading to low energy, difficulty concentrating, and increased emotional distress. To improve sleep quality:

  • Stick to a consistent bedtime and wake-up schedule
  • Avoid screens (phones, tablets, TVs) at least an hour before bed
  • Create a relaxing nighttime routine, such as reading or taking a warm bath
  • Limit caffeine and heavy meals in the evening

If sleep problems persist, talk to your doctor about potential solutions.

Make Exercise a Routine

Physical activity has been shown to boost mood by increasing endorphins and serotonin, chemicals in the brain that help regulate emotions. Regular exercise doesn’t have to be intense—even daily walks, gardening, or gentle stretching can make a difference. Activities like swimming, biking, or dancing may also improve energy levels and reduce stress.

Work Closely with Your Mental Health Provider

Be open with your doctor about what’s working, what’s not, and how you’re feeling. The right combination of treatments, medications, and lifestyle changes can help you achieve long-term improvement.

By combining medical treatments with these supportive lifestyle adjustments, individuals struggling with TRD can improve their overall mental health and well-being.

A group who has found feeling from treatment resistant depression raleigh

How Our Raleigh Psychiatry Experts Can Help

At MedPsych, we take a comprehensive and patient-centered approach to care. If you’re seeking TRD treatment in Raleigh, here’s what you can expect when working with us:

  • Thorough Evaluation – We assess your medical history, past treatments, and overall health to identify the best next steps.
  • Personalized Treatment Plan – Every person is unique, so we tailor treatments to your specific needs.
  • Ongoing Support & Monitoring – We track progress, make necessary adjustments, and ensure you receive continuous care.

Compassionate Care for Treatment-Resistant Depression in Raleigh

If you feel stuck in a battle with depression despite treatment, you are not alone. Many individuals experience TRD, but with the right approach, improvement is possible. At MedPsych, we specialize in treatment-resistant depression in Raleigh and provide compassionate, expert care to help you reclaim your life. 

Connect with us today and explore the advanced treatments available to you.

Request an Appointment

With emerging Technology, it has never been easier to connect with a doctor. Schedule a virtual visit today and gain the hope for a better tomorrow

Choose your appointment type

We’ll get in touch with you shortly to book your appointment.

Request an appointment.

We’ll get in touch with you shortly to book your appointment.

1 / 7
2 / 7
3 / 7
4 / 7
5/ 7
6/ 7
7/ 7